LactoVance Innovation

MastisGUARD™

Dual-Action Udder Health Adjunct

A mastitis-focused adjunct built around Copper Alpha-Ketoglutarate (Cu-AKG) — supporting udder immune defense, antioxidant balance, and recovery as part of veterinarian-guided mastitis management programs.

Cu-AKG Adjunct Udder Health Support Prevention + Recovery
Fortify
Adjunct support for immune readiness and udder resilience against mastitis pathogens.
Recover
Adjunct support to manage inflammation and oxidative stress during recovery.
Milk Quality
Adjunct support for SCC stability and production consistency in real farm conditions.
Clinical Validation Plan Partner / Invest
Healthy dairy cow close-up
Cow udder health
Udder Health
Dairy herd
Herd Management
Veterinary science
Veterinary Science
R&D research
R&D
Why MastisGUARD™ Exists

Mastitis needs more than antibiotics alone

Subclinical cases often go unnoticed while steadily reducing production efficiency and raising somatic cell count. MastisGUARD™ is designed as a non-antibiotic adjunct pathway — supporting prevention, resilience, and recovery alongside veterinarian-guided treatment programs.

The Problem
Farm-level impact that adds up
  • Milk loss and discarded milk during withdrawal periods
  • Higher veterinary and labor costs per case
  • Recurrence and chronic udder tissue damage
  • Increased culling risk for high-value animals
  • Antibiotic residue pressure — adjunct alternatives are increasingly demanded
The Opportunity
Industry is moving toward adjunct solutions
Dairy systems worldwide are under pressure to maintain milk quality while reducing unnecessary antibiotic use — increasing demand for supportive, evidence-aligned adjunct solutions that can be integrated into existing veterinarian-guided programs.
MastisGUARD™ is positioned precisely at this intersection: clinical credibility, farm practicality, and a clear evidence validation path.
Milk quality
Active Ingredient

Copper Alpha-
Ketoglutarate
Cu-AKG

Cu-AKG is a novel compound combining copper — essential for immune function and antioxidant defense — with alpha-ketoglutarate, a key metabolic intermediate. Together, they support the biological pathways most relevant to udder health and mastitis resilience.

01
Immune Cell Support
Copper supports neutrophil and macrophage activity — the first line of udder defense against bacterial invasion.
02
Antioxidant Defense
Cu-AKG supports superoxide dismutase activity, helping manage reactive oxygen species produced during mammary inflammation.
03
Metabolic Recovery Support
Alpha-ketoglutarate supports energy metabolism and tissue regeneration pathways during and after infection.
04
Transition Period Resilience
Targeted adjunct support during the high-risk peri-parturient period when immune suppression elevates mastitis susceptibility.
Cows grazing
Farm Practical
Herd of cows
Farmer Focused
Buffalo
Evidence-Led
Adjunct Benefits

What MastisGUARD™ is designed to support

Across dairy animals, farms, and supply chains — MastisGUARD™ is built to deliver measurable adjunct value at every stage of the mastitis management cycle.

01
Immune Defense Support
Adjunct support for immune cell function against mastitis-causing bacteria at the teat canal and udder level.
02
Oxidative Balance
Antioxidant defense support to manage oxidative stress during mammary inflammation and infection events.
03
Inflammation & Recovery
Adjunct support to reduce udder inflammation burden and promote tissue recovery stability post-infection.
04
SCC & Milk Quality
Adjunct support for lowering somatic cell count and maintaining milk quality consistency across the herd.
05
Recurrence Reduction
Adjunct support to help reduce repeat infections and chronic subclinical mastitis pressure over time.
Farm practical adjunct protocol
Farm-practical adjunct protocol

Value for Dairy Farmers & milk buyers

By reducing mastitis burden and stabilizing milk quality, MastisGUARD™ supports farm profitability and supply reliability through an adjunct pathway designed to pair with existing veterinarian-guided programs.

Supports lower antibiotic pressure Veterinarian-guided Supply chain confidence
Preventive & Medicinal Benefits

The full spectrum of MastisGUARD™ action

Cu-AKG delivers interlocking preventive and medicinal benefits — from immune fortification and antioxidant protection through to tissue repair, SCC management, and long-term herd resilience.

Enhances Immune Function Against Mastitis Pathogens
Cu-AKG activates multiple layers of innate and adaptive immunity to directly combat the bacteria responsible for bovine mastitis.
CopperAKGNeutrophilsMacrophages
Immune Cell Production
Copper supports the production and function of immune cells like Neutrophils and Macrophages that kill mastitis-causing bacteria (e.g., Staphylococcus, Streptococcus, E. coli).
Antibody Production
Boosts production of Cytokines and antibodies needed to fight infection.
Immune Cell Energy
AKG provides an energy substrate to immune cells, enhancing their activity and longevity.
Potent Antioxidant Defence
MastisGUARD™ neutralizes the oxidative damage that worsens mastitis outcomes and prolongs recovery time.
CopperAKGSOD EnzymeROS Reduction
SOD Enzyme Support
Copper is a key component of Superoxide Dismutase (SOD), an enzyme that neutralizes free radicals produced during mastitis inflammation.
Reactive Oxygen Species
AKG also helps reduce Reactive Oxygen Species (ROS), minimizing tissue damage in the udder.
Reduces Udder Inflammation
Dual-action anti-inflammatory support that calms acute swelling while maintaining the balanced immune response needed to contain infection.
AKGCopperAnti-inflammatoryTissue Restoration
Anti-inflammatory Effects
AKG has anti-inflammatory effects that help calm swelling and redness in infected mammary tissue. Copper maintains a balanced inflammatory response.
Resolution & Restoration
Supports faster resolution of inflammation and restoration of udder tissue.
Accelerates Tissue Repair & Re-Generation
Supports the structural rebuilding of damaged mammary tissue — promoting collagen synthesis, restoring udder integrity, and returning the gland to full productive capacity.
CopperAKGCollagen SynthesisEpithelial Regeneration
Collagen & Wound Healing
Copper is vital for Collagen Synthesis, promoting healing of damaged udder tissues. Restores udder integrity post-infection.
Milk Production Recovery
Supports epithelial regeneration, restoring milk production capacity following mastitis events.
Protein Synthesis
Enhances protein synthesis via its role in nitrogen metabolism.
Lowers Somatic Cell Count (SCC)
Reduces the key milk quality indicator — supporting lower SCC scores, improved bulk tank results, and premium milk pricing compliance.
CopperAKGSCC ReductionMilk Quality
Inflammation & SCC Link
Improved inflammation control and decreased inflammatory mediators result in a significant reduction in Somatic Cell Count (SCC).
Pathogen Control
Copper helps maintain udder integrity and mount a rapid cell defense response.
Black Milk Prevention
Helps reduce Chronic or Subclinical mastitis which is common in high-yielding cows.
Reduces / Prevents Recurrence of Mastitis
Builds lasting udder resilience to break the cycle of chronic and repeat mastitis infections.
CopperAKGLong-term ImmunityHerd Health
Long-term Immune Resilience
Strengthens long-term immune resilience in the mammary gland, reducing the likelihood of recurring infection.
Chronic Mastitis Reduction
Helps reduce Chronic or Subclinical mastitis which is common in high-yielding cows.
Yield & Quality Protection
Copper supplementation helps: Lower SCC, Improve milk yield and quality, Reduce discard.
Improves Response to Health Treatment
Works synergistically with conventional veterinary therapies — supporting faster recovery, reducing treatment duration, and improving overall herd health outcomes.
Adjunct TherapyAntibiotic SupportNSAID SupportOverall Immunity
Antibiotic Synergy
Copper AKG can work as a Synergistic or Supportive Adjunct to antibiotic therapy. May allow for lower antibiotic doses or shorter treatment periods.
Overall Immunity Boost
Strengthens Overall Immunity, indirectly protecting the mammary gland.
Supports Overall Milk Production and Recovery
Directly supports the return of normal milk yield and quality following mastitis events — protecting the economic productivity of the herd.
Milk YieldSCC ReductionPost-infection RecoveryQuality Milk
SCC & Milk Flow
By reducing SCC and inflammation, Copper AKG helps reduce milk loss from mastitis. Promotes recovery of milk yield post-infection.
Yield Recovery
Promotes recovery of milk yield post-infection.
Helps During Transition Period
Targeted support during the highest-risk window in a dairy cow's production cycle — when immune suppression peaks and mastitis susceptibility is at its greatest.
Peri-parturientImmune PreparationPreventive SupportTherapeutic Use
Yield Maintenance
During transition, Copper AKG supports immune preparedness against mastitis. Useful in both Preventive and Therapeutic programs.
Shield & Heal — The Dual-Action Nutritional Adjunct
MastisGUARD™ works on two fronts simultaneously: shielding the udder from pathogen invasion and healing tissue damage once infection occurs.
PreventiveMedicinalDual-ActionConventional Therapy Adjunct
Dual-Action Adjunct
The dual-action nutritional adjunct that helps prevent health, fight infection, and speed recovery — naturally.
Conventional Therapy Support
Can be given as an adjunct to conventional health therapy (e.g. Antibiotics or Anti-inflammatories) to improve recovery and prevent/reduce recurrence.
Usage & Protocol

Designed for real farm workflows

MastisGUARD™ is designed to fit practical on-farm protocols across three key use contexts — each under veterinarian guidance and evidence-backed positioning.

Phase 01
Preventive Adjunct Program
Used as part of an ongoing herd health program to support immune readiness, udder resilience, and baseline SCC management — especially during higher-risk periods like transition.
Evidence approach
Phase 02
Acute Recovery Support
Deployed alongside conventional mastitis therapy (antibiotics or NSAIDs) as an adjunct to support inflammatory management, oxidative balance, and tissue recovery after clinical events.
Trial protocol
Phase 03
Recurrence Management
For cows with chronic or repeat mastitis history — adjunct support to reduce the likelihood of recurrence, support udder tissue health, and stabilize milk quality over the longer term.
Partner program

MastisGUARD™ is positioned as a nutritional adjunct. It is not intended to diagnose, treat, cure, or prevent disease. Product use and claims must align with label, evidence, and veterinary guidance. Clinical validation is ongoing.

Ready to validate
the MastisGUARD™ opportunity?

We're seeking clinical partners and investors to accelerate the evidence pathway — from trial protocol to launch-ready commercial positioning.

Clinical Validation Plan Partner / Invest Contact the Team